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KMID : 0385520140270040196
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Analytical Science & Technology
2014 Volume.27 No. 4 p.196 ~ p.200
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Development of alternative titration method without mercuric acetate for the assay of difemerine hydrochloride in Korean Pharmaceutical Codex
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Jeon Sang-Seol
Kim Kyeong-Ho
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Abstract
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Currently nonaqueous titration method for the assay method using the hazardous reagent, mercury acetate for difemerine hydrochloride has been used in Korean Pharmaceutical Codex. We developed an alternative titration assay method by substituting the use of the hazardous reagent, mercury acetate to the use of less toxic ones like ethyl alcohol. The linearity of the calibration curves in the desired concentration range was good (r>0.999). Precision was less than 0.64%. Accuracy was obtained with recoveries in range of 99.10% and 99.71%. The developed assay could be expected to become valuable tools for revising the Korean Pharmaceutical Codex
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KEYWORD
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Korean Pharmaceutical Codex, hazardous reagents, alternative testing methods, validation, titration,
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